Does Aging Cause Vitamin Deficiencies?

Written by Kathleen Doheny

Reviewed by Louise Chang, MD on November 30, 2012

Nov. 30, 2012 — At least half of adults age 65 and above take daily vitamins and other supplements, but only a fraction actually need them, says an Emory University expert.

The majority of older adults, he says, can improve their diet to get needed nutrients.

“A lot of money is wasted in providing unnecessary supplements to millions of people who don’t need them,” says Donald B. McCormick, PhD, an Emory professor emeritus of biochemistry and the graduate program in nutrition and health sciences at Emory.

He challenges what he says is a widely held belief that the older people get, the more vitamins and mineral supplements they need.

The scientific backup for that doesn’t exist, he says. “We know too little to suggest there is a greater need in the elderly for most of these vitamins and minerals.”

“A supplement does not cure the aging process,” he says. And in some cases, supplements may do harm, he says. Expense is another factor.

His report, which reviews numerous studies of vitamins and mineral supplements, is published in Advances in Nutrition.

Duffy MacKay, ND, vice president of scientific and regulatory affairs for the Council for Responsible Nutrition, an industry group representing dietary supplement makers, agrees that starting with a good diet is the best way to get needed nutrients.

But he says that is not always reality, especially for older adults who may have obstacles such as a reduced appetite.

Older-Adult Nutrient Needs

McCormick reviewed studies on dietary supplements in older adults published in the last 12 years.

He says that ”it is apparent that changes in requirements for the elderly do not suggest massive supplement use covering most micronutrients.” He says minor diet changes can fill needs for nutrients, ”with supplements included only where there is evidence of serious limitation of intake.”

He disagrees with a study suggesting that older adults should take two multivitamins a day. He found no evidence that older adults need more thiamin, riboflavin, or niacin than younger people. Some older adults may need more vitamin B6, B12, and folate, research suggests.

But vitamin C needs do not seem to change with age, he says, if an older adult does not smoke cigarettes.

McCormick also found no evidence that absorption or the body’s use of vitamin E changes as people get older. He says there is a decrease in the way the skin makes vitamin D. So for some older adults, supplemental vitamin D may be needed. In some research, taking 800 to 1,000 IUs of vitamin D a day helped women who were past menopause.

Copper requirements don’t seem to change with age, either, McCormick says.

Older adults often take in less chromium, but he says there is not evidence that there are any health consequences.

In his report, McCormick says supplements for cancer patients are not recommended. (His report was finalized before recent research linked the use of a daily multivitamin to decreased cancer risk modestly in male doctors age 50 and older.) “The jury is still out.” (SJF).

For older adults, McCormick has this advice: “If you are still eating fairly well, you are getting more micronutrients than you probably really need to function as well as you can.”

Boosting nutrients above what can be gotten from a well-balanced diet won’t necessarily lead to better health, he says.

At very high levels, some vitamins and minerals can be toxic, he says.

Perspectives: Vitamins, Supplements for Older Adults

”The adequate intake of vitamins in the elderly is a concern,” MacKay of the Council for Responsible Nutrition says.

In particular, he says, older adults may lack calcium, vitamin D, vitamin B12, potassium, and fiber.

Changing the diet can be difficult for older people, he says. Living on fixed incomes may make fresh produce too costly.

Some older adults don’t know how to cook. For others, ill-fitting dentures or a reduced appetite may make eating difficult.

“Where dietary changes are difficult, a dietary supplement can be a responsible, reasonable solution,” he says.

The Academy of Nutrition and Dietetics says older adults should pay special attention to their intake of calcium, vitamin D, vitamin B-12, potassium, and fiber.

Fortified milk and yogurt can boost calcium and vitamin D. Lean meat, fortified cereal, and some fish and seafood have vitamin B12. Fruits and vegetables have potassium and fiber.

“It’s always best to obtain your nutrients from food,” says Andrea Giancoli, RD, MPH, a spokeswoman for The Academy of Nutrition and Dietetics. She reviewed the report for WebMD.

When she counsels older adults, Giancoli first figures out what nutrients are lacking in the diet. Often, it’s vitamin D, calcium, and vitamin B12.

“I try to fix it with food,” she says. For instance, she suggests someone with calcium deficits increase their dairy products.

“I don’t think we should be recommending supplements blindly without assessing their food intake,” she says.

Bottom Line:

“Supplements are a multi-billion-dollar industry, and a lot of that is marketing. But the argument that supplments are useless and everybody should stop wasting their money is also overblown: There are gaps left by the typical American diet, and those gaps can be plugged with the judicious use of supplements. But if your diet is good, the supplements you take should be minimal.”

Source: Mark Bittman and David L. Katz, MD. How to Eat: All your food and diet questions answered. 2020

From SJF: Supplements should not be taken in what is found in many popular products and dosages called megadoses, Some supplements can be toxic, i.e.amounts in huge percentages over the RDA. These values can be found in any nutrition textbook as Tolerable Upper Intake Levels (UL) for Vitamins and Tolerable Uppper Intake Levels (UL) for Minerals and reading supplement labels can provide megadose amounts if present in the product. Consult your doctor who may have prescribed these doses for a medical problem.

SOURCES:

Donald B. McCormick, PhD, professor emeritus of biochemistry and graduate program in nutrition and health sciences, Emory University, Atlanta.

Duffy MacKay, ND, vice president of scientific and regulatory affairs, The Council for Responsible Nutrition.

Andrea Giancoli, MPH, RD, spokesperson, The Academy of Nutrition and Dietetics.

McCormick D. Advances in Nutrition, November 2012.

Vitamin D and Mortality – In the News

Improving vitamin D levels in Older Age is Linked to Lower risk of all-cause Mortality

Sources: BMC Geriatr 22, 245 (2022)
LIfe Extension, Feb. 2023

Judith E. Brown. Nutrition Now, 7th Edition

The participants in this study included 1,362 individuals in the Chinese Longitudinal and Health Longitudinal Survey, aged 60 to 113 whose serum vitamin D levels were measured in 2012 and 2014. Mortality data were collected in 2018.

Deficient vitamin D levels were detected in 67.5% of the participants in 2012 and 68.4% in 2014.

During follow-up, 420 deaths occurred. Individuals who were deficient in vitamin D in 2012 and 2014 had more than twice the mortality risk than those who maintained higher levels.

Among participants who maintained sufficient vitamin D were deficient in 2012 and not deficient in 2014, the risk of dying was 30% and 53% lower, respectively, compared to participants who were deficient at both points in time.

This highlights the need to address vitamin D deficiency in older individuals to support longevity and healthy aging.

Editor’s Note: The greatest benefit associated with improved vitamin D status was found among women and those people who were 80 years of age or older.

What are the primary functions of vitamin D? This fat-soluble vitamin is needed for absorption of calcium and phosphorus needed for bone formation and muscle activity. It inhibits inflammation and is involved in insulin secretion and blood glucose level maintenance. It can be toxic with the long term use of 10,000 IU daily. The RDA is 600 IU for adult women and men; the Upper Tolerable Intake (UL) is 4,000 IU.s or 100 ug.

This highlights the need to address vitamin D deficiency in older individuals. Based on the evidence for bone benefits, however, a nutrition panel recently increased the RDA for vitamin D to 600 IU for people up to age 70 and to 800 IU for those over 70. That’s a fairly sizable boost over the previous recommendations of 200 IU per day through age 50, 400 IU for ages 51 to 70, and 600 IU for ages over 70. They also raised the safe upper limit of daily intake for most age groups from 2,000 to 4,000 IU. to support longevity and healthy aging. 1 microgram vitamin D = 40 IU as both terms are used on supplement labels. It is primarily found only in vitamin D-fortified milk, cereals, and other foods such as fish.

The best way to measure effects of supplemental intake or vitamin D status is by a blood test. Vitamin D3 is the most active form and is made from a form of cholesterol in the skin cells upon exposure to ultraviolet rays from the sun. See your doctor for guidance.

All About Vitamin B12

Disclaimer

This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. We encourage you to talk to your health care providers (doctor, registered dietitian, pharmacist, etc.) about your interest in, questions about, or use of dietary supplements and what may be best for your overall health. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice.

What is vitamin B12 and what does it do?

Vitamin B12 is a nutrient that helps keep your body’s blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak.

How much vitamin B12 do I need?

The amount of vitamin B12 you need each day depends on your age. Average daily recommended amounts for different ages are listed below in micrograms (mcg):

Life StageRecommended Amount
Birth to 6 months0.4 mcg
Infants 7–12 months0.5 mcg
Children 1–3 years0.9 mcg
Children 4–8 years1.2 mcg
Children 9–13 years1.8 mcg
Teens 14–18 years2.4 mcg
Adults2.4 mcg
Pregnant teens and women2.6 mcg
Breastfeeding teens and women2.8 mcg

What foods provide vitamin B12?

Vitamin B12 is found naturally in a wide variety of animal foods, and manufacturers add it to some fortified foods. Plant foods have no vitamin B12 unless they are fortified. You can get recommended amounts of vitamin B12 by eating a variety of foods including the following:

  • Fish, meat, poultry, eggs, milk, and other dairy products contain vitamin B12.
  • Clams and beef liver are some of the best source of vitamin B12.
  • Some breakfast cereals, nutritional yeasts, and other food products are fortified with vitamin B12.

To find out if a food has added vitamin B12, check the Nutrition Facts label. Manufacturers are not required to list vitamin B12 on the label if a food naturally contains this vitamin.

What kinds of vitamin B12 dietary supplements are available?

Vitamin B12 is available in multivitamin/multimineral supplements, in B-complex supplements, and in supplements containing only vitamin B12. It is usually in a form called cyanocobalamin. Other common forms are adenosylcobalamin, methylcobalamin, and hydroxycobalamin. Vitamin B12 is also available in a form that’s dissolved under your tongue (called sublingual vitamin B12). Research has not shown that any form of supplemental vitamin B12 is better than the others.

The amount of vitamin B12 in supplements varies widely. Some provide doses of vitamin B12 that are much higher than recommended amounts, such as 500 mcg or 1,000 mcg, but your body absorbs only a small percentage of it. These doses are considered safe. Check the Supplement Facts label to see how much vitamin B12 a supplement contains.

A prescription form of vitamin B12 can be given as a shot. This is usually used to treat vitamin B12 deficiency. Vitamin B12 is also available by prescription as a nasal gel that’s sprayed into the nose.

Am I getting enough vitamin B12?

Most people in the United States get enough vitamin B12 from the foods they eat. But some people have trouble absorbing vitamin B12 from food. The body absorbs vitamin B12 from food in a two-step process. First, hydrochloric acid in the stomach separates vitamin B12 from the protein that it’s attached to. Second, the freed vitamin B12 then combines with a protein made by the stomach, called intrinsic factor, and the body absorbs them together.

Vitamin B12 in dietary supplements isn’t attached to protein and doesn’t require the first step. However, B12 in supplements does need to combine with intrinsic factor to be absorbed.

People with pernicious anemia, an autoimmune disease, can’t make intrinsic factor. As a result, they have trouble absorbing vitamin B12 from foods and dietary supplements.

Vitamin B12 deficiency affects between 3% and 43% of older adults. Your doctor can test your vitamin B12 level to see if you have a deficiency.

Certain groups of people may not get enough vitamin B12 or have trouble absorbing it:

  • Many older adults don’t have enough hydrochloric acid in their stomach to absorb the vitamin B12 that’s naturally present in food. People over 50 should get most of their vitamin B12 from fortified foods or dietary supplements because, in most cases, their bodies can absorb vitamin B12 from these sources.
  • People with an autoimmune disease called atrophic gastritis might not absorb enough vitamin B12 because they make too little hydrochloric acid and intrinsic factor in their stomach.
  • People with pernicious anemia do not make the intrinsic factor needed to absorb vitamin B12. As a result, they have trouble absorbing vitamin B12 from foods and dietary supplements. Doctors usually treat pernicious anemia with vitamin B12 shots, although very high doses of vitamin B12 given by mouth might also be effective.
  • People who have had some types of stomach or intestinal surgery (for example, to lose weight or to remove part or all of the stomach) might not make enough hydrochloric acid and intrinsic factor to absorb vitamin B12.
  • People with disorders of the stomach and small intestine, such as celiac disease or Crohn’s disease, might not absorb enough vitamin B12.
  • People who eat little or no animal foods, such as vegetarians and vegans, might not get enough vitamin B12 from their diets. Only animal foods have vitamin B12 naturally. When pregnant women and women who breastfeed their babies are strict vegetarians or vegans, their babies might also not get enough vitamin B12.

What happens if I don’t get enough vitamin B12?

Your body stores 1,000 to 2,000 times as much vitamin B12 as you’d typically eat in a day, so the symptoms of vitamin B12 deficiency can take several years to appear.

If you have a vitamin B12 deficiency, you may feel tired or weak. These are symptoms of megaloblastic anemia, which is a hallmark of vitamin B12 deficiency. You might also have pale skin, heart palpitations, loss of appetite, weight loss, and infertility. Your hands and feet might become numb or tingly, a sign of nerve problems. Other symptoms of vitamin B12 deficiency include problems with balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue.

Vitamin B12 deficiency can damage the nervous system even in people who don’t have megaloblastic anemia, so it’s important to treat a deficiency as soon as possible.

What are some effects of vitamin B12 on health?

Scientists are studying vitamin B12 to understand how it affects health. Here are several examples of what this research has shown.

Heart disease and stroke
Vitamin B12 supplements (along with other B vitamins) reduce blood levels of homocysteine, a compound linked to an increased risk of having a heart attack or stroke But despite reducing homocysteine, research shows that these vitamins don’t reduce the risk of developing cardiovascular disease or stroke.

Dementia and cognitive function
Most studies show that low blood levels of vitamin B12 don’t affect the risk of cognitive decline in older people, regardless of whether they have dementia or Alzheimer’s disease. More clinical trials are needed to better understand the effects of vitamin B12 supplementation on cognitive function in older adults.

Energy and Endurance
Manufacturers often promote vitamin B12 supplements for energy, athletic performance, and endurance. But vitamin B12 doesn’t provide these benefits in people who get enough B12 from their diet.

Can vitamin B12 be harmful?

Vitamin B12 has not been shown to cause any harm, even at high doses.

Does vitamin B12 interact with medications or other dietary supplements?

Yes. Vitamin B12 supplements can interact or interfere with some medicines that you take. Here are several examples.

Gastric acid inhibitors
People take gastric acid inhibitors to treat certain digestion problems, such as gastroesophageal reflux disease and peptic ulcer disease. These drugs can interfere with vitamin B12 absorption from food by slowing the release of hydrochloric acid into the stomach, leading to vitamin B12 deficiency. Gastric acid inhibitors include omeprazole (Prilosec®), lansoprazole (Prevacid®), cimetidine (Tagamet®), and ranitidine (Zantac®).

Vitamin B12 and healthful eating

People should get most of their nutrients from food and beverages, according to the federal government’s Dietary Guidelines for Americans. Foods contain vitamins, minerals, dietary fiber, and other components that benefit health. In some cases, fortified foods and dietary supplements are useful when it is not possible to meet needs for one or more nutrients (for example, during specific life stages such as pregnancy).

Who Needs Vitamin B12?

Vitamin B12 helps maintain nerve tissues, aids in reactions that build up protein tissues

Needed for normal red blood cell development.

Older people, those who have had stomach surgery and vegans are at risk for vitamin B12 deficiency. Some people become deficient in B12 because they are unable to absorb it.

Vitamin B12 is found in animal products and microorganisms only.

SOURCE:

GAPLES INSTITUTE

Author: Stephen Devries, MD

CLICK HERE.

All about omega-3 fats and the Brain : Source: Medical News Today

The following study presents an interesting connection between omega-3 fats, brain function and cognitive decline.

Erica Watts, Oct 7, 2022

Fact Checked by Alexandra Sanfins, PhD.

  • Omega-3 fatty acids have many benefits and play a role in heart health and cognitive functioning.
  • A new study demonstrates that there may be a connection between consuming omega-3 and an increase in brain functioning for people in midlife.
  • The cross-sectional study analyzed the omega-3 blood levels of people in their midlife and assessed their MRIs and thinking skills to see whether there was a difference in people with higher or lower omega-3 levels.

“According to the new study published in Neurology, the medical journal of the American Academy of Neurology, people who have higher omega-3 levels in their middle ages may have an edge over people who take in lower levels of omega-3.

The study was led by researchers at the University of Texas Health at San Antonio, TX, who were concerned about the lack of research on how omega-3 can impact people in their midlife.

Omega-3: Things to know

According to the National Institutes of Health (NIH)Trusted Source, omega-3 fatty acids “are a group of polyunsaturated fatty acids that are important for a number of functions in the body.” In addition to playing a role in heart health and cognitive functioning, omega-3 fatty acids are also part of the cell membraneTrusted Source and affect cell functioning.

As Professor Stuart Phillips noted during a Live Long and Master Aging podcast, “Some fats that we ingest, and particularly the omega-3 or long-chain polyunsaturated fatty acids are actually what we refer to as essential fats. We need to have them in our diet because we don’t have the ability to make them ourselves.”

Prof. Phillips is the director of the Physical Activity Center of Excellence at McMaster University in Ontario, Canada.

The NIHTrusted Source lists three types of omega-3 fatty acids: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)..

While people can take omega-3 supplements, it is also in a number of foods. Some good sources of omega-3 include fish (such as salmon and tuna) nuts and seeds (chia seeds and flax seeds).

Studying Omega-3’s effect

The researchers studied 2,183 men and women with an average age of 46. They excluded people who had dementia or a history of having a stroke from their participant pool.

Omega-3s are present in the brain, particularly in the hippocampus. The hippocampus plays a role in learning and memory, and a reduction in the volume can point to possible dementiaTrusted Source.

The participants also underwent a neurological assessment. The tests measured the participants’ abstract thinking, processing speed, executive function, and delayed episodic memory.

Omega-3 and brain health 

Using blood samples, the researchers analyzed the fatty acid composition (omega-3’s) of each participant. The participants also consented to having their brains scanned using MRI technology. The researchers were also interested in the volumes of gray and white matter.

The researchers placed approximately 25% of the participants in the low group where the participants had omega-3 fatty acids blood levels falling under 4%. This group had an average count of 3.4%.

The rest of the participants were put into the high group; their average omega-3 level was 5.2%.

Comparing the blood samples, MRI results, and neurological assessments, the study authors determined that higher levels of omega-3 fatty acids correlate to a higher hippocampus volume and better abstract reasoning.

Researchers observed that the people in the high group also had higher gray matter volumes, better reading scores, and slightly higher logical reasoning scores.

In contrast, the people in the low group tended to be less likely to have a college degree and more likely to be smokers and have diabetes compared to the higher group.

“This exploratory study suggests that higher [omega-3 blood levels] are associated with larger hippocampal volumes and better performance in abstract reasoning, even in cognitively healthy middle-aged adults from the community, suggesting a possible role in improving cognitive resilience,” write the authors.

“These results need to be confirmed with additional research, but it’s exciting that omega-3 levels could play a role in improving cognitive resilience, even in middle-aged people,” said study author Prof. Claudia L. Satizabal, Ph.D.

Prof. Satizabal is an assistant professor at the Department of Population Health Sciences at UT Health San Antonio, TX.

Diet and brain health 

The authors noted that other researchers have conducted similar studies in older populations but believe that it is necessary to see what impacts omega-3 supplements have on people in their midlife because they start experiencing cognitive decline.

According to the authors, “One of the main challenges for some of these studies may be that dietary interventions are carried out perhaps too late for significant improvements in symptomatic participants, as cognitive changes may be well established over the previous 15 to 20 years.”

“Improving our diet is one way to promote our brain health. If people could improve their cognitive resilience and potentially ward off dementia with some simple changes to their diet, that could have a large impact on public health.”

– Prof. Satizabal

Dr. Natalie King, a neuroscientist and founder of Florae Beauty, not involved in the study, spoke with Medical News Today and discussed the importance of diets on brain health.

“Everything we do and consume affects our brain, and there have been numerous studies, including the one shared, that highlight the effects of food and drink on overall brain health and function,” said Dr. King.

“Omega-3 fatty acids, in particular, have been found to be beneficial when it comes to improving mental function as well as supporting an overall wellness plan when considering disease pathologies like mood disorders and others affecting learning and memory,” Dr. King continued.”

Until we know how much omega-3 fats are needed to improve optimal brain function in the meantime, adequate EPA and DHA dosage is often obtained by consuming 8 ounces of fatty fish weekly. Deep fried fish have been found to be a poorer source of EPA and DHA than baked or broiled fish. The top sources include: salmon, farmed and wild, anchovies, herring, whitefish, mackerel, and sardines. Tuna (light) canned in oil only provides lower amounts.

Judith E. Brown, Nutrition Now, 7th Edition.

Supplements are plentiful on the market; however, consult your physician for dosage and any conflicts with other medications such as blood thinners. It is important to remember that dietary supplements are produced and marketed with few regulations as to safety, quality or efficacy.

Do Seniors Need a Daily Boost?

Daily multivitamins help keep seniors’ brains sharp, may ward off dementia

September 14, 2022

by John Anderer

WINSTON-SALEM, N.C. — Could the secret to a sharp brain in old age be as simple as taking a daily multivitamin? New joint research from Wake Forest University and Brigham and Women’s Hospital suggests as much. Scientists conclude that multivitamins can improve thinking skills in older individuals and help stave off cognitive decline.

Study authors note that the findings are still preliminary and require further confirmation before any concrete health recommendations can be made. Nonetheless, establishing a new, affordable such as taking a daily multivitamin way to fight cognitive decline and dementia in old age could potentially benefit millions. Today, over 6.5 million Americans are living with Alzheimer’s disease (the most common form of dementia), and a staggering one in three senior citizens pass away with Alzheimer’s or another form of dementia.

“There’s an urgent need for safe and affordable interventions to protect cognition against decline in older adults,” says Dr. Laura D. Baker, a professor of gerontology and geriatric medicine at Wake Forest University School of Medicine and co-principal investigator of the trial, in a statement. Baker worked alongside Dr. Mark Espeland, also a professor of gerontology and geriatric medicine at Wake Forest.

Multivitamins versus cocoa extract

This project, named the COcoa Supplement and Multivitamin Outcomes Study for the Mind (COSMOS-Mind), was funded by the National Institute on Aging of the National Institutes of Health. Participants include 21,442 men and women living all over the United States.

Researchers investigated if taking either a daily cocoa extract supplement or a daily multivitamin-mineral supplement would influence health outcomes and risk profiles in relation to heart disease, stroke, cancer, and other health issues. Why cocoa extract? Prof. Baker explains cocoa extract is rich in compounds known as flavanolsPrior research suggests flavanols may have a positive influence on cognition. Moreover, deficiencies in several essential micronutrients and minerals among older adults may increase the risk for cognitive decline and dementia.

The research team tested the daily intake of a placebo versus a cocoa extract supplement, as well as the daily intake of a multivitamin-mineral versus a placebo. Over 2,200 participants, all aged 65 years and older, were tracked for a period of three years. Additionally, subjects completed memory and cognition tests over the phone at baseline and on an annual basis.

‘First evidence of cognitive benefit in large longer-term study’

“Our study showed that although cocoa extract did not affect cognition, daily multivitamin-mineral supplementation resulted in statistically significant cognitive improvement,” Prof. Baker explains. “This is the first evidence of cognitive benefit in a large longer-term study of multivitamin supplementation in older adults.”

Study authors estimate taking a multivitamin for three years roughly translates to a “60 percent slowing of cognitive decline (about 1.8 years)”. They also note the benefits were especially pronounced among those with significant cardiovascular disease.

“It’s too early to recommend daily multivitamin supplementation to prevent cognitive decline,” Baker concludes. “While these preliminary findings are promising, additional research is needed in a larger and more diverse group of people. Also, we still have work to do to better understand why the multivitamin might benefit cognition in older adults.”

The study is published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

Omega 3 Fats and Cognition

In 2016 a large study confirmed findings from 21 cohort studies (181,000 people)that supported that fish consumption was protective against the risk of dementia and Alzheimer’s disease. It was published in the American Journal of Clinical Nutrition and recommended “fishery products” for a lower risk of cognitive impairment.

Source: Y. Zhang, et al., “Intakes of Fish and Polyunsaturated Fatty Acids and Mild-to-Severe Cognitive Impairment Risks: A Dose-Response Meta-Analysis of 21 Cohort Studies, American Journal of Clinical Nutrition 103, no 2 (2016):330-40.

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Are Herbal Supplements Safe?

Are Herbal Supplements Helpful or Harmful?

 Herbal supplements are popular as “natural” remedies. Are they useful for health or are they a health risk? Today, about 1 in 6 Americans use herbs to treat everything from coughs, constipation, and poison ivy, and arthritis. They are widely available and affordable and don’t require a prescription. Advocates claim this makes people more in control of their own health care; opponents fear that self-dosing may lead to toxic interactions and prevent people from seeking traditional care and proven treatments offered by conventional practitioners.

Some herbs are derived from plants in the first place. For example, aspirin comes from willow bark and digitalis from foxglove flowers to treat certain heart problems.  The active ingredients may come from all the parts of the plant, so the amounts contained are affected by harvesting and processing and vary with the batch. This practice may further upset the balance of the ingredients and the doses are often affected. Herbs are made from unpurified plant material, and there is also a risk of contamination with pesticides, microbes, metals and other unnamed toxins.  

Another concern is that some herbs interact with prescription drugs and cause additional problems. For example, gingko biloba and garlic can interfere with blood clotting and should not be used with blood-thinners before surgery. St. John’s wort may interact with anesthetics and antidepressants.

 Herbs are medicines and like taking other medications has some advantages and risks. Whether they are helpful or harmful depends on the supplement, the dose, and the consumer. Education is essential in the pros and cons of any medication as well as herbal remedies. The best advice is “buyer beware”.  This advice applies to all dietary supplements due to a lack of much-needed regulations on safety and effectiveness.

Alternative Medicine?

Complementary and Alternative Medicine Practices

Consumer interest in alternative medical practices has been around for several decades – the last known data acknowledges that at least 34% of people recently surveyed in the U.S. used some type of alternative, complementary and integrative medicine in the past year. This resulted in about $30 billion generated to this industry. (2016 Data)

Most alternative medicine consumers have illnesses for which conventional medicine cannot offer a cure, such as arthritis, terminal stages of AIDS, and stress-related conditions. The mind is a powerful component of many of the treatments, which is proven in many trials as a placebo effect. There are lots of possible reasons that something like a folk medicine or a homeopathic preparation may work. In addition to belief of the mind-body effects of the “medication” as well as the normal ups and downs of symptoms, the remission of the disease, the denial of symptoms or misrepresentation of effectiveness by people who believe the remedy is effective. The body can be a powerful healer under the right conditions.

Many clients wish physicians would take the time to explain (in simple terms) the nature of the problem, to acknowledge nutritional influences on health, rather than just recommend drugs and surgery as the only approaches for treating illness; to answer questions about dietary supplements, be sensitive to mind-body interactions, and to respect questions about alternative therapies. My Granddaughter is in her second year of medical school – I will be anxious to hear how and if she receives any of these practices in her training.

To date, few alternative therapies have been subjected to scientific scrutiny, and many of the practices are based on presumptions that are unconvincing at best, yet some, e.g. acupuncture and chiropractic show promise in certain conditions.

Herbal medicine.   By definition, an herb is a plant or any of its parts that is used primarily for medicinal purposes. This includes aromatherapy. Dosage forms include capsules, tablets, extracts, or tinctures, powders, teas, creams, and ointments. In March 1999, FDA established regulations that require the labels of such supplements to include name, quantity, dosage per day, and ingredient amounts.

Fraudulent claims for diet-and health related remedies have always been a part of our culture. It is important to scrutinize the credentials and motives of anyone providing medical or health advice. “Let the buyer beware.” Unfortunately, if it sounds too good to be true, it probably is.

Reference: Gordon M. Wardlaw. Contemporary Nutrition, Issues, and Insights. Fifth Edition.

Homocysteine and Heart Disease

What is Homocysteine?  

Homocysteine is an amino acid produced in the body during the metabolism of a common dietary amino acid called methionine. Vitamins B6, B12, riboflavin and folate help breakdown homocysteine into other beneficial amino acids.

Deficiencies in these vitamins may lead to elevated homocysteine levels a condition known as hyperhomocysteinemia. When homocysteine levels are elevated,  they are associated with the development of atherosclerosis, stroke, cognitive disorders, and hearing loss. Elevated homocysteine is a risk factor for vascular calcification progression suggested in a study published in 2020 in the Journal of the American Heart Association. It effects the calcification of arteries and heart valves and is considered an irreversible state. Homocysteine may also increase blood clotting, reduce the synthesis of HDL, (good cholesterol), and promote the oxidation of LDL which contributes to atherosclerosis.

Brain Aging

When the MRI scans of 36 healthy volunteers between the ages of 59 and 85 were done, it was revealed that those with higher homocysteine levels had a greater loss of white matter, defined as brain tissue for nerve signal conduction.

There is some evidence that elevated homocysteine may indicated markers of Alzheimer’s disease progression in brain tissue including neurofibrillary tangles, dysfunction, dysfunctional protein accumulation, and brain shrinkage.

Studies have also shown that even modest elevations of homocysteine that occur within the normal range has been associated with a substantial increase in risk of dementia in the elderly.

Prevention

It is recommended that if you have a history of heart disease or dementia, you should talk to your physician as there are simple blood tests to determine your homocysteine status. It is also recommended that if your levels go above the recommended levels, you have a choice to supplement your diet with a common multivitamin that contains vitamin B6, folate, B12, and riboflavin – they all work to lower homocysteine concentrations in the body.  However, it is not necessary to take individual vitamins that are more costly and frankly a ‘lot of pills to take”. Vitamins are best coming from foods and check your health status to make sure there are no underlying conditions that might be caused by even a moderate vitamin deficit. Check your status with your primary care physician.

THE VITAMINS AT A GLANCE

VitaminFunctionOverdose ConsequenceFood SourcesComments
B6 (pyridoxine)Protein synthesis, nervous systemNumbness,  weakness, loss of balanceMeats, cereal, bananas, potatoes sweet peppersOverdose symptoms can mask multiple sclerosis
Folate (folacin)Protein synthesis, red blood formationCan mask B12 deficiency (pernicious anemia)Fortified grains, bread, pasta, dark green vegetables, dried beansPrevention of neural tube defects in early pregnancy of embryo
B12Nerve tissues, red blood cell formation None knownFish, seafood, milk, cheese, meatFound in animal products and microorganisms only
RiboflavinEnergy release from carbsNone knownMilk, yogurt, cheese, grains, eggs, liver, fish, beefDestroyed by light exposure