How is Your Vitamin D Status?

Are you feeling the effects of aging? If so you may at some time be told to check your vitamin D level. Vitamin D has recently become a very popular vitamin as a cure-all supplement (until another takes it place.) I think of vitamin D as a nutrient looking for a disease. So, the two have yet to meet ( in my opinion). Vitamin D is associated with strength and bone health primarily for children. However, more research is needed.

This is what we think we know: In the field of nutrition, this may change overnight.

The precursors for vitamin D are reduced as we age. By age 70, our ability to produce vitamin D is about half of what it was at age 20. D is in scarce supply in our regular diets. Most milk and some juices, milk alternatives and cereals are fortified with D, but other dietary sources — fatty fish like mackerel and sardines, and some mushrooms — aren’t exactly a staple in most American diets. As a result, nearly 1 in 4 people in the U.S. have inadequate blood levels of vitamin D3, the most active form.

In one study of adults 50 and older, all of whom had recently fractured bones, 43 percent were deficient in both calcium and vitamin D. Presently the world has turned to taking supplements in “megadoses” to meet the recent claims that vitamin D can be the cure-all for all the recent diseases like Parkinson’s disease, cognitive decline, Alzheimer’s disease, heart disease – in other words, maybe vitamin D has found its disease. Not so fast!!

It is not necessary to take most vitamins at megadose levels (unless ordered by your doctor).
But… How much do you really need?

Before you pick up a vitamin D supplement, it makes sense to have a conversation with your doctor. Vitamin D can interact with heart medications, including statins and diuretics. Dietary guidelines call for 600 international units (IUs) daily of vitamin D3 (and at least 800 after age 70). So that’s a solid place to start. Look for vitamin D3, which is more efficiently utilized by the body than D2. The Tolerable Upper Intake is 4000 IU per day for adults. Many people are prescribed higher levels depending on a latest study they read from a headline in a supermarket magazine; however, please check with your doctor, health coach or registered dietitian.
Since we also manufacture vitamin D from cholesterol and from the sun, we can count on that source somewhat depending on your exposure.

Ways to Improve Vitamin D Status – Source:
Judith E Brown.Nutrition Now, 7th Edition

Eat salmon once a week
Choose a vitamin D-fortified orange juice when I buy juice
Take a vitamin supplement (400-600 IU/day )
Exercise or walk in sunshine for 10 minutes three times a day with some direct skin exposure to the sun.

American Plate: 1930’s

Merry Christmas and a HAPPY NEW YEAR from Food, Facts, and Fads

Hard Times, Good Times

Here’s Another Story from Another Era

The 1930’s  were a dichotomy of despair and progress.  Two grim events dominated the 30’s: the global depression and the rise of Hitler and nationalism in Europe. In the midst of all the upheaval another dramatic change – In 1933, Prohibition was finally repealed. Oh and throw in a disastrous Dust Storm that lasted far too long.

The nation goes gaga over vitamins in the 30s. The only over-the-counter products that outsell them are laxatives. Where is the fiber?

Cooking at home became a necessity and a pastime among middle-aged women who had been forced to let their cooks and servants go. Women’s clubs lunches, afternoon teas, Sunday suppers, potluck dinners, church socials and county fairs were all popular ways to socialize.

Hollywood provided a steady stream of fantasy with Fred Astaire, Ginger Rogers, Clark Gable and Jean Harlow, and Shirley Temple. Cole Porter’s musicals ruled Broadway and Benny Goodman’s dance tunes played on Victrolas everywhere.

Soup Kitchens

For more than a decade known as the Great Depression, reliance on businesses had failed that they could not solve the problems of poverty including hunger. Local governments tried to help the needy, but expenditures, which averaged $8.20 per month per person did nothing to help the thousands more who required federal aid. Thus, organizations like the Red Cross and the Salvation army provided help through soup kitchens and breadlines: 13 million people –25 percent of the population—were unemployed and hungry.

Route 66

Route 66

Despite the odds, America forged ahead and with the opening of Route 66, food establishments like Stuckeys flourished. In the supermarkets, scores of new products were introduced and many still exist today.

When U.S. highway 66 was completed in 1938, it became a vital 2450- mile artery between Chicago and Los Angeles, snaking its way through 8 states. It veered north then south to pass through small towns to link them with more metropolitan cities. With the route, farmers had a pipeline for shipping their food to the big cities and offer help to those trapped by the tragic Dust Bowl that filled the lives of those farmers in that area. Stukeys gets its start when William and Ethyl Stuckey open a roadside stand in Georgia to sell pecans to motorists en route to and from Florida.

Shopping carts

I suppose no one is terribly interested in the history of the shopping cart; however, it is an appliance of sorts we could not do without. So here goes: Slyvan Goldman, owner of the Standard Food Markets and Humpty Dumpty in Oklahoma City, devised a shopping cart by fabricating lawn chairs into a frame that held two hand baskets. He figured if the shoppers could carry more, they’ll buy more. But the first shopping cart is a hard sell. Men found the carts less than masculine and women don’t see the point – they’re accustomed to shopping often. Finally Goldman pays ‘shoppers to cruise stores using the carts.

Kraft Dinner

In 1937, Spam is introduced – yes it’s still here. Kraft rolls out Kraft Dinner – a boxed meal that sells for 19 cents with an advertising slogan of “A Meal for Four in Nine Minutes”.  At the end of the century, 1 million boxes a day of Kraft Macaroni & Cheese are sold in the U.S. Talk about processed food?? Apparently this has pleased the palates of our younger citizens for decades.

Fritos

San Antonio candy-maker C. Elmer Doolin stops in  a café for a sandwich and is served a side dish of corn chips. He pays the café owner for $100 for his converted potato ricer and the recipe for “tortillas fritas”. Fritos are born, as Doolin and his family begin producing 10 pounds per day. They eventually move their operation to Dallas. Fritos Corn Chips are introduced nationally in 1949.

At the end of the decade, WW2 was boiling in Europe with America waiting in the wings. The “Bad Times” were just beginning.

Association of fish and long-chain 3 -omega fatty intakes with total and cause-specific mortality: prospective analysis of 421,309 individuals.

Association of fish and long-chain omega-3 fatty acids intakes with total and cause-specific mortality: prospective analysis of 421 309 individuals
Y Zhang  1 , P Zhuang  1 , W He  2 , J N Chen  1 , W Q Wang  3 , N D Freedman  4 , C C Abnet  4 , J B Wang  5 , J J Jiao  3

A study published in the Journal of Internal Medicine reported that both men and women who had a high intake of fish or long-chain omega 3 polyunsaturated fatty acids (PUFA) that included EPA, DHA, and DPA had lower risks of dying from any cause.

The study population included 240, 729 men and 180,580 women. They were given questionnaires concerning lifestyle and diet and followed up after 16 years.

Results (from Abstract)
“A total of 54 230 men and 30 882 women died during 6.07 million person-years of follow-up. Higher fish and LCn-3 PUFAs intakes were significantly associated with lower total mortality (P < 0.0001). Comparing the highest with lowest quintiles of fish intake,
men had 9% (95% confidence interval, 6–11%) lower total mortality, 10% (6–15%) lower cardiovascular disease (CVD) mortality, 6% (1–10%) lower cancer mortality, 20% (11–28%) lower respiratory disease mortality and 37% (17–53%) lower chronic liver disease mortality, while women had 8% (5–12%) lower total mortality, 10% (3–17%) lower CVD mortality and 38% (20–52%) lower Alzheimer’s disease mortality. Fried fish consumption was not related to mortality in men whereas positively associated with mortality from all causes (P = 0.011), CVD and respiratory disease in women. LCn-3 PUFAs intake was associated with 15% and 18% lower CVD mortality in men and women across extreme quintiles, respectively.”

Conclusion
“Consumption of fish and LCn-3 PUFAs was robustly associated with lower mortality from major causes. Our findings support current guidelines for fish consumption while advice on non-frying preparation methods is needed.
Discussion: “As the associations between long-chain omega-3 PUFAS intake and morality were similar to that of fish intake, the health benefits of fish is probably related to the abundant content of long-chain omega-3 PUFAS, which possess anti-inflammatory properties and may prevent the development of inflammation-driven disorders, including cardiovascular disease, cancer, and Alzlheimer’s disease,” Dr. Zhang and associates observed.”
“Overall, we provide new clinical evidence with which to address the role of fish and long-chain omega-3 PUFAs in overall health and contribute to updated dietary guidelines,” the authors concluded.”
A study reported on July 18, 2018 in the Journal of Internal Medicine reveals a lower risk of dying from any cause during a 16-year follow-up period among men and women who had a high intake of fish or long-chain omega-3 polyunsaturated fatty acids (PUFAs), which include EPA, DHA, and DPA.”

Keywords: AARP diet and health study; cardiovascular disease; long-chain omega-3 fatty acids; marine fish; mortality.
© 2018 The Association for the Publication of the Journal of Internal Medicine.

Before taking any PUFA supplement, check with your physician. Fish is better!!! SJF

From Eating Well:

The Bottom Line: “If you tend to eat a lot of fried food, the air fryer is definitely a good option for you. Still, the air fryer isn’t a magic machine that makes any food “healthy.” If you typically use the oven to cook food, the air fryer can be a great tool to add more variety to your cooking—start experimenting with our 30-Minute Recipes for Your Air Fryer! From Eating Well.”

Vitamin B12: The Facts At a Glance

Important Facts about Vitamin B12
Sally Feltner MS, PhD Diet and Health, General October 15, 2020 2 Minutes
March 27, 2019 by foodworksblog Leave a comment


Vitamin B12 is often overlooked as to its importance to human health. Vitamin B12 is needed for the metabolism of another vitamin, folate as well as fatty acids to maintain the insulating layer of myelin surrounding nerve fibers. When myelin degenerates, neurological symptoms occur that include numbness, tingling, memory loss and disorientation. If not treated, it can eventually cause paralysis and death. On the other hand, a deficiency is rare, but can be a public health concern due to marginal B12 status due to either low intake or problems with absorption as often found in the older adult. This deficiency may also occur in people who attempt to practice a strict vegan diet as this vitamin is found almost exclusively in animal products.Vegan diets are a concern due to B12 found only in animal foods. Severe deficiencies have been found in breast – fed infants of vegan women and marginal deficiencies for all vegans if supplemental or fortified foods are not consumed in the diet.

The absorption of B12 from food requires adequate levels of stomach acid, intrinsic factor (produced in the stomach) and pancreatic secretions. Even though it is a water-soluble vitamin, the body stores and reuses it more efficiently that it does other water soluble vitamins. Poor absorption of vitamin B12 can result from a condition called pernicious anemia. It is an autoimmune disease in which the cells in the stomach that produce intrinsic factor are destroyed. This can be treated by using injections or megadoses of the vitamin. When this occurs, intrinsic factor is not necessary since synthetic B12 found in supplements are used that bypass the digestive system.

Primary Food Sources
Fish, seafood
Meat
Milk and cheese
Ready to eat cereals

Highlights and Comments
Older people, those with previous stomach surgery, and vegans are at risk for deficiency.
Some people become B12 deficient because they are unable to absorb it (pernicious anemia).
Vitamin B12 is found in animal products and microorganisms only.

Source: Smolin, Lori A. & , Grosvenor, Mary B. Nutrition, Science and Applications, Third Edition
Judith E. Brown, Nutrition Now, 7th Edition

Medscape News

Can taking vitamin D supplements help prevent dementia?

Scientists say there may be an interesting link between vitamin D supplements and dementia.

  • Researchers assessed the association between vitamin D supplementation and the incidence of dementia.
  • They found that vitamin D supplementation was linked to a lower dementia incidence.
  • Further studies are needed to certify the results.

Over 55 million people live with dementia worldwide, which is expected to rise to 139 million by 2050Trusted Source. There are currentlyTrusted Source no medications that can stop or reverse the condition.

Interventions that can affect dementia risk factors are being explored to slow disease progression. One such risk factor is vitamin D deficiency.

Some studies have found that vitamin D may aid the clearance of amyloid beta aggregates—one of the hallmarks of Alzheimer’s disease (AD). However, studies have produced conflicting results on whether vitamin D improves cognitive function.

Other studiesTrusted Source show that low vitamin D levels are linked to a greater risk of dementia and AD.

Further studying the link between vitamin D supplementation and cognitive decline could help develop preventative strategies for dementia.

Recently, researchers assessed the link between vitamin D supplementation and incident dementia. They found that vitamin D supplementation is linked to lower incidence of dementia.

The study was published in Alzheimer’s and Dementia: Diagnosis, Assessment & Disease MonitoringTrusted Source.

Note: A word of caution – please discuss news like this with your primary care physician or a certificated registered nutritionist. We also make Vitamin D from sun exposure. It is also found in fortified milk, some fish, and fortified cereals.

Vitamin D is a fat soluble vitamin and stored in the body. The consequences of overdose are: metal retardation in children, abnormal bone growth and formation, nausea, diarrhea, irritability, deposition of calcium in organs such as kidney, liver, and heart.

Toxicity is possible with long-term use of 10,000 IU daily. Judith E. Brown, Nutrition Now, 7th Edition.

Sally Feltner, MS, PhD.

Does Aging Cause Vitamin Deficiencies?

Written by Kathleen Doheny

Reviewed by Louise Chang, MD on November 30, 2012

Nov. 30, 2012 — At least half of adults age 65 and above take daily vitamins and other supplements, but only a fraction actually need them, says an Emory University expert.

The majority of older adults, he says, can improve their diet to get needed nutrients.

“A lot of money is wasted in providing unnecessary supplements to millions of people who don’t need them,” says Donald B. McCormick, PhD, an Emory professor emeritus of biochemistry and the graduate program in nutrition and health sciences at Emory.

He challenges what he says is a widely held belief that the older people get, the more vitamins and mineral supplements they need.

The scientific backup for that doesn’t exist, he says. “We know too little to suggest there is a greater need in the elderly for most of these vitamins and minerals.”

“A supplement does not cure the aging process,” he says. And in some cases, supplements may do harm, he says. Expense is another factor.

His report, which reviews numerous studies of vitamins and mineral supplements, is published in Advances in Nutrition.

Duffy MacKay, ND, vice president of scientific and regulatory affairs for the Council for Responsible Nutrition, an industry group representing dietary supplement makers, agrees that starting with a good diet is the best way to get needed nutrients.

But he says that is not always reality, especially for older adults who may have obstacles such as a reduced appetite.

Older-Adult Nutrient Needs

McCormick reviewed studies on dietary supplements in older adults published in the last 12 years.

He says that ”it is apparent that changes in requirements for the elderly do not suggest massive supplement use covering most micronutrients.” He says minor diet changes can fill needs for nutrients, ”with supplements included only where there is evidence of serious limitation of intake.”

He disagrees with a study suggesting that older adults should take two multivitamins a day. He found no evidence that older adults need more thiamin, riboflavin, or niacin than younger people. Some older adults may need more vitamin B6, B12, and folate, research suggests.

But vitamin C needs do not seem to change with age, he says, if an older adult does not smoke cigarettes.

McCormick also found no evidence that absorption or the body’s use of vitamin E changes as people get older. He says there is a decrease in the way the skin makes vitamin D. So for some older adults, supplemental vitamin D may be needed. In some research, taking 800 to 1,000 IUs of vitamin D a day helped women who were past menopause.

Copper requirements don’t seem to change with age, either, McCormick says.

Older adults often take in less chromium, but he says there is not evidence that there are any health consequences.

In his report, McCormick says supplements for cancer patients are not recommended. (His report was finalized before recent research linked the use of a daily multivitamin to decreased cancer risk modestly in male doctors age 50 and older.) “The jury is still out.” (SJF).

For older adults, McCormick has this advice: “If you are still eating fairly well, you are getting more micronutrients than you probably really need to function as well as you can.”

Boosting nutrients above what can be gotten from a well-balanced diet won’t necessarily lead to better health, he says.

At very high levels, some vitamins and minerals can be toxic, he says.

Perspectives: Vitamins, Supplements for Older Adults

”The adequate intake of vitamins in the elderly is a concern,” MacKay of the Council for Responsible Nutrition says.

In particular, he says, older adults may lack calcium, vitamin D, vitamin B12, potassium, and fiber.

Changing the diet can be difficult for older people, he says. Living on fixed incomes may make fresh produce too costly.

Some older adults don’t know how to cook. For others, ill-fitting dentures or a reduced appetite may make eating difficult.

“Where dietary changes are difficult, a dietary supplement can be a responsible, reasonable solution,” he says.

The Academy of Nutrition and Dietetics says older adults should pay special attention to their intake of calcium, vitamin D, vitamin B-12, potassium, and fiber.

Fortified milk and yogurt can boost calcium and vitamin D. Lean meat, fortified cereal, and some fish and seafood have vitamin B12. Fruits and vegetables have potassium and fiber.

“It’s always best to obtain your nutrients from food,” says Andrea Giancoli, RD, MPH, a spokeswoman for The Academy of Nutrition and Dietetics. She reviewed the report for WebMD.

When she counsels older adults, Giancoli first figures out what nutrients are lacking in the diet. Often, it’s vitamin D, calcium, and vitamin B12.

“I try to fix it with food,” she says. For instance, she suggests someone with calcium deficits increase their dairy products.

“I don’t think we should be recommending supplements blindly without assessing their food intake,” she says.

Bottom Line:

“Supplements are a multi-billion-dollar industry, and a lot of that is marketing. But the argument that supplments are useless and everybody should stop wasting their money is also overblown: There are gaps left by the typical American diet, and those gaps can be plugged with the judicious use of supplements. But if your diet is good, the supplements you take should be minimal.”

Source: Mark Bittman and David L. Katz, MD. How to Eat: All your food and diet questions answered. 2020

From SJF: Supplements should not be taken in what is found in many popular products and dosages called megadoses, Some supplements can be toxic, i.e.amounts in huge percentages over the RDA. These values can be found in any nutrition textbook as Tolerable Upper Intake Levels (UL) for Vitamins and Tolerable Uppper Intake Levels (UL) for Minerals and reading supplement labels can provide megadose amounts if present in the product. Consult your doctor who may have prescribed these doses for a medical problem.

SOURCES:

Donald B. McCormick, PhD, professor emeritus of biochemistry and graduate program in nutrition and health sciences, Emory University, Atlanta.

Duffy MacKay, ND, vice president of scientific and regulatory affairs, The Council for Responsible Nutrition.

Andrea Giancoli, MPH, RD, spokesperson, The Academy of Nutrition and Dietetics.

McCormick D. Advances in Nutrition, November 2012.

Vitamin D and Mortality – In the News

Improving vitamin D levels in Older Age is Linked to Lower risk of all-cause Mortality

Sources: BMC Geriatr 22, 245 (2022)
LIfe Extension, Feb. 2023

Judith E. Brown. Nutrition Now, 7th Edition

The participants in this study included 1,362 individuals in the Chinese Longitudinal and Health Longitudinal Survey, aged 60 to 113 whose serum vitamin D levels were measured in 2012 and 2014. Mortality data were collected in 2018.

Deficient vitamin D levels were detected in 67.5% of the participants in 2012 and 68.4% in 2014.

During follow-up, 420 deaths occurred. Individuals who were deficient in vitamin D in 2012 and 2014 had more than twice the mortality risk than those who maintained higher levels.

Among participants who maintained sufficient vitamin D were deficient in 2012 and not deficient in 2014, the risk of dying was 30% and 53% lower, respectively, compared to participants who were deficient at both points in time.

This highlights the need to address vitamin D deficiency in older individuals to support longevity and healthy aging.

Editor’s Note: The greatest benefit associated with improved vitamin D status was found among women and those people who were 80 years of age or older.

What are the primary functions of vitamin D? This fat-soluble vitamin is needed for absorption of calcium and phosphorus needed for bone formation and muscle activity. It inhibits inflammation and is involved in insulin secretion and blood glucose level maintenance. It can be toxic with the long term use of 10,000 IU daily. The RDA is 600 IU for adult women and men; the Upper Tolerable Intake (UL) is 4,000 IU.s or 100 ug.

This highlights the need to address vitamin D deficiency in older individuals. Based on the evidence for bone benefits, however, a nutrition panel recently increased the RDA for vitamin D to 600 IU for people up to age 70 and to 800 IU for those over 70. That’s a fairly sizable boost over the previous recommendations of 200 IU per day through age 50, 400 IU for ages 51 to 70, and 600 IU for ages over 70. They also raised the safe upper limit of daily intake for most age groups from 2,000 to 4,000 IU. to support longevity and healthy aging. 1 microgram vitamin D = 40 IU as both terms are used on supplement labels. It is primarily found only in vitamin D-fortified milk, cereals, and other foods such as fish.

The best way to measure effects of supplemental intake or vitamin D status is by a blood test. Vitamin D3 is the most active form and is made from a form of cholesterol in the skin cells upon exposure to ultraviolet rays from the sun. See your doctor for guidance.

All About Vitamin B12

Disclaimer

This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. We encourage you to talk to your health care providers (doctor, registered dietitian, pharmacist, etc.) about your interest in, questions about, or use of dietary supplements and what may be best for your overall health. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice.

What is vitamin B12 and what does it do?

Vitamin B12 is a nutrient that helps keep your body’s blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak.

How much vitamin B12 do I need?

The amount of vitamin B12 you need each day depends on your age. Average daily recommended amounts for different ages are listed below in micrograms (mcg):

Life StageRecommended Amount
Birth to 6 months0.4 mcg
Infants 7–12 months0.5 mcg
Children 1–3 years0.9 mcg
Children 4–8 years1.2 mcg
Children 9–13 years1.8 mcg
Teens 14–18 years2.4 mcg
Adults2.4 mcg
Pregnant teens and women2.6 mcg
Breastfeeding teens and women2.8 mcg

What foods provide vitamin B12?

Vitamin B12 is found naturally in a wide variety of animal foods, and manufacturers add it to some fortified foods. Plant foods have no vitamin B12 unless they are fortified. You can get recommended amounts of vitamin B12 by eating a variety of foods including the following:

  • Fish, meat, poultry, eggs, milk, and other dairy products contain vitamin B12.
  • Clams and beef liver are some of the best source of vitamin B12.
  • Some breakfast cereals, nutritional yeasts, and other food products are fortified with vitamin B12.

To find out if a food has added vitamin B12, check the Nutrition Facts label. Manufacturers are not required to list vitamin B12 on the label if a food naturally contains this vitamin.

What kinds of vitamin B12 dietary supplements are available?

Vitamin B12 is available in multivitamin/multimineral supplements, in B-complex supplements, and in supplements containing only vitamin B12. It is usually in a form called cyanocobalamin. Other common forms are adenosylcobalamin, methylcobalamin, and hydroxycobalamin. Vitamin B12 is also available in a form that’s dissolved under your tongue (called sublingual vitamin B12). Research has not shown that any form of supplemental vitamin B12 is better than the others.

The amount of vitamin B12 in supplements varies widely. Some provide doses of vitamin B12 that are much higher than recommended amounts, such as 500 mcg or 1,000 mcg, but your body absorbs only a small percentage of it. These doses are considered safe. Check the Supplement Facts label to see how much vitamin B12 a supplement contains.

A prescription form of vitamin B12 can be given as a shot. This is usually used to treat vitamin B12 deficiency. Vitamin B12 is also available by prescription as a nasal gel that’s sprayed into the nose.

Am I getting enough vitamin B12?

Most people in the United States get enough vitamin B12 from the foods they eat. But some people have trouble absorbing vitamin B12 from food. The body absorbs vitamin B12 from food in a two-step process. First, hydrochloric acid in the stomach separates vitamin B12 from the protein that it’s attached to. Second, the freed vitamin B12 then combines with a protein made by the stomach, called intrinsic factor, and the body absorbs them together.

Vitamin B12 in dietary supplements isn’t attached to protein and doesn’t require the first step. However, B12 in supplements does need to combine with intrinsic factor to be absorbed.

People with pernicious anemia, an autoimmune disease, can’t make intrinsic factor. As a result, they have trouble absorbing vitamin B12 from foods and dietary supplements.

Vitamin B12 deficiency affects between 3% and 43% of older adults. Your doctor can test your vitamin B12 level to see if you have a deficiency.

Certain groups of people may not get enough vitamin B12 or have trouble absorbing it:

  • Many older adults don’t have enough hydrochloric acid in their stomach to absorb the vitamin B12 that’s naturally present in food. People over 50 should get most of their vitamin B12 from fortified foods or dietary supplements because, in most cases, their bodies can absorb vitamin B12 from these sources.
  • People with an autoimmune disease called atrophic gastritis might not absorb enough vitamin B12 because they make too little hydrochloric acid and intrinsic factor in their stomach.
  • People with pernicious anemia do not make the intrinsic factor needed to absorb vitamin B12. As a result, they have trouble absorbing vitamin B12 from foods and dietary supplements. Doctors usually treat pernicious anemia with vitamin B12 shots, although very high doses of vitamin B12 given by mouth might also be effective.
  • People who have had some types of stomach or intestinal surgery (for example, to lose weight or to remove part or all of the stomach) might not make enough hydrochloric acid and intrinsic factor to absorb vitamin B12.
  • People with disorders of the stomach and small intestine, such as celiac disease or Crohn’s disease, might not absorb enough vitamin B12.
  • People who eat little or no animal foods, such as vegetarians and vegans, might not get enough vitamin B12 from their diets. Only animal foods have vitamin B12 naturally. When pregnant women and women who breastfeed their babies are strict vegetarians or vegans, their babies might also not get enough vitamin B12.

What happens if I don’t get enough vitamin B12?

Your body stores 1,000 to 2,000 times as much vitamin B12 as you’d typically eat in a day, so the symptoms of vitamin B12 deficiency can take several years to appear.

If you have a vitamin B12 deficiency, you may feel tired or weak. These are symptoms of megaloblastic anemia, which is a hallmark of vitamin B12 deficiency. You might also have pale skin, heart palpitations, loss of appetite, weight loss, and infertility. Your hands and feet might become numb or tingly, a sign of nerve problems. Other symptoms of vitamin B12 deficiency include problems with balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue.

Vitamin B12 deficiency can damage the nervous system even in people who don’t have megaloblastic anemia, so it’s important to treat a deficiency as soon as possible.

What are some effects of vitamin B12 on health?

Scientists are studying vitamin B12 to understand how it affects health. Here are several examples of what this research has shown.

Heart disease and stroke
Vitamin B12 supplements (along with other B vitamins) reduce blood levels of homocysteine, a compound linked to an increased risk of having a heart attack or stroke But despite reducing homocysteine, research shows that these vitamins don’t reduce the risk of developing cardiovascular disease or stroke.

Dementia and cognitive function
Most studies show that low blood levels of vitamin B12 don’t affect the risk of cognitive decline in older people, regardless of whether they have dementia or Alzheimer’s disease. More clinical trials are needed to better understand the effects of vitamin B12 supplementation on cognitive function in older adults.

Energy and Endurance
Manufacturers often promote vitamin B12 supplements for energy, athletic performance, and endurance. But vitamin B12 doesn’t provide these benefits in people who get enough B12 from their diet.

Can vitamin B12 be harmful?

Vitamin B12 has not been shown to cause any harm, even at high doses.

Does vitamin B12 interact with medications or other dietary supplements?

Yes. Vitamin B12 supplements can interact or interfere with some medicines that you take. Here are several examples.

Gastric acid inhibitors
People take gastric acid inhibitors to treat certain digestion problems, such as gastroesophageal reflux disease and peptic ulcer disease. These drugs can interfere with vitamin B12 absorption from food by slowing the release of hydrochloric acid into the stomach, leading to vitamin B12 deficiency. Gastric acid inhibitors include omeprazole (Prilosec®), lansoprazole (Prevacid®), cimetidine (Tagamet®), and ranitidine (Zantac®).

Vitamin B12 and healthful eating

People should get most of their nutrients from food and beverages, according to the federal government’s Dietary Guidelines for Americans. Foods contain vitamins, minerals, dietary fiber, and other components that benefit health. In some cases, fortified foods and dietary supplements are useful when it is not possible to meet needs for one or more nutrients (for example, during specific life stages such as pregnancy).

Who Needs Vitamin B12?

Vitamin B12 helps maintain nerve tissues, aids in reactions that build up protein tissues

Needed for normal red blood cell development.

Older people, those who have had stomach surgery and vegans are at risk for vitamin B12 deficiency. Some people become deficient in B12 because they are unable to absorb it.

Vitamin B12 is found in animal products and microorganisms only.

SOURCE:

GAPLES INSTITUTE

Author: Stephen Devries, MD

CLICK HERE.

All about omega-3 fats and the Brain : Source: Medical News Today

The following study presents an interesting connection between omega-3 fats, brain function and cognitive decline.

Erica Watts, Oct 7, 2022

Fact Checked by Alexandra Sanfins, PhD.

  • Omega-3 fatty acids have many benefits and play a role in heart health and cognitive functioning.
  • A new study demonstrates that there may be a connection between consuming omega-3 and an increase in brain functioning for people in midlife.
  • The cross-sectional study analyzed the omega-3 blood levels of people in their midlife and assessed their MRIs and thinking skills to see whether there was a difference in people with higher or lower omega-3 levels.

“According to the new study published in Neurology, the medical journal of the American Academy of Neurology, people who have higher omega-3 levels in their middle ages may have an edge over people who take in lower levels of omega-3.

The study was led by researchers at the University of Texas Health at San Antonio, TX, who were concerned about the lack of research on how omega-3 can impact people in their midlife.

Omega-3: Things to know

According to the National Institutes of Health (NIH)Trusted Source, omega-3 fatty acids “are a group of polyunsaturated fatty acids that are important for a number of functions in the body.” In addition to playing a role in heart health and cognitive functioning, omega-3 fatty acids are also part of the cell membraneTrusted Source and affect cell functioning.

As Professor Stuart Phillips noted during a Live Long and Master Aging podcast, “Some fats that we ingest, and particularly the omega-3 or long-chain polyunsaturated fatty acids are actually what we refer to as essential fats. We need to have them in our diet because we don’t have the ability to make them ourselves.”

Prof. Phillips is the director of the Physical Activity Center of Excellence at McMaster University in Ontario, Canada.

The NIHTrusted Source lists three types of omega-3 fatty acids: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)..

While people can take omega-3 supplements, it is also in a number of foods. Some good sources of omega-3 include fish (such as salmon and tuna) nuts and seeds (chia seeds and flax seeds).

Studying Omega-3’s effect

The researchers studied 2,183 men and women with an average age of 46. They excluded people who had dementia or a history of having a stroke from their participant pool.

Omega-3s are present in the brain, particularly in the hippocampus. The hippocampus plays a role in learning and memory, and a reduction in the volume can point to possible dementiaTrusted Source.

The participants also underwent a neurological assessment. The tests measured the participants’ abstract thinking, processing speed, executive function, and delayed episodic memory.

Omega-3 and brain health 

Using blood samples, the researchers analyzed the fatty acid composition (omega-3’s) of each participant. The participants also consented to having their brains scanned using MRI technology. The researchers were also interested in the volumes of gray and white matter.

The researchers placed approximately 25% of the participants in the low group where the participants had omega-3 fatty acids blood levels falling under 4%. This group had an average count of 3.4%.

The rest of the participants were put into the high group; their average omega-3 level was 5.2%.

Comparing the blood samples, MRI results, and neurological assessments, the study authors determined that higher levels of omega-3 fatty acids correlate to a higher hippocampus volume and better abstract reasoning.

Researchers observed that the people in the high group also had higher gray matter volumes, better reading scores, and slightly higher logical reasoning scores.

In contrast, the people in the low group tended to be less likely to have a college degree and more likely to be smokers and have diabetes compared to the higher group.

“This exploratory study suggests that higher [omega-3 blood levels] are associated with larger hippocampal volumes and better performance in abstract reasoning, even in cognitively healthy middle-aged adults from the community, suggesting a possible role in improving cognitive resilience,” write the authors.

“These results need to be confirmed with additional research, but it’s exciting that omega-3 levels could play a role in improving cognitive resilience, even in middle-aged people,” said study author Prof. Claudia L. Satizabal, Ph.D.

Prof. Satizabal is an assistant professor at the Department of Population Health Sciences at UT Health San Antonio, TX.

Diet and brain health 

The authors noted that other researchers have conducted similar studies in older populations but believe that it is necessary to see what impacts omega-3 supplements have on people in their midlife because they start experiencing cognitive decline.

According to the authors, “One of the main challenges for some of these studies may be that dietary interventions are carried out perhaps too late for significant improvements in symptomatic participants, as cognitive changes may be well established over the previous 15 to 20 years.”

“Improving our diet is one way to promote our brain health. If people could improve their cognitive resilience and potentially ward off dementia with some simple changes to their diet, that could have a large impact on public health.”

– Prof. Satizabal

Dr. Natalie King, a neuroscientist and founder of Florae Beauty, not involved in the study, spoke with Medical News Today and discussed the importance of diets on brain health.

“Everything we do and consume affects our brain, and there have been numerous studies, including the one shared, that highlight the effects of food and drink on overall brain health and function,” said Dr. King.

“Omega-3 fatty acids, in particular, have been found to be beneficial when it comes to improving mental function as well as supporting an overall wellness plan when considering disease pathologies like mood disorders and others affecting learning and memory,” Dr. King continued.”

Until we know how much omega-3 fats are needed to improve optimal brain function in the meantime, adequate EPA and DHA dosage is often obtained by consuming 8 ounces of fatty fish weekly. Deep fried fish have been found to be a poorer source of EPA and DHA than baked or broiled fish. The top sources include: salmon, farmed and wild, anchovies, herring, whitefish, mackerel, and sardines. Tuna (light) canned in oil only provides lower amounts.

Judith E. Brown, Nutrition Now, 7th Edition.

Supplements are plentiful on the market; however, consult your physician for dosage and any conflicts with other medications such as blood thinners. It is important to remember that dietary supplements are produced and marketed with few regulations as to safety, quality or efficacy.