Covid and Fish Oil?

Salmon and vegetables on a dinner plate
Salmon and other seafood types are one of the best foods for protein.(Photo by cattalin on pixabay.com)

Covid-19 News

Still worried about COVID? Eating more oily fish may protect you

March 17, 2023

by Shyla Cadogan

SIOUX FALLS, S.D. — Oily fish are a part of many healthy diets, mainly because of the omega-3 fatty acids they carry. Studies show they have the ability to boost brain health and may even reduce the risk of heart disease. Now, there’s even more reason to add salmon or sardines to your diet. Scientists report that omega-3 fatty acids can also help protect against severe cases of COVID-19.

A team of researchers from the Fatty Acid Research Institute and the University of South Dakota designed a study that compared the risk for three COVID-19 scenarios: testing positive, hospitalization, and death as a function of baseline plasma DHA levels. DHA is an omega-3 fatty acid, which is abundant in fish like salmon. EPA is another fatty acid also found in oily fish. The team examined the implications of adding both to someone’s diet.

https://b5c290d7f3674d0d7b0e2b3e92ef07e7.safeframe.googlesyndication.com/safeframe/1-0-40/html/container.html

They measured the percent of total fatty acids (DHA levels) using Nuclear Magnetic Resonance (NMR) spectroscopy and converted them into an Omega-3 Index, which includes the percentages of red blood cell EPA and DHA for actual analysis. Their work included information from a sample of 110,584 people (COVID hospitalizations and deaths), as well as 26,595 individuals with just a positive test result, pulled from the UK Biobank. The outcomes were assessed from January 2020 to March 2021.

High omega-3 levels cut down COVID risk by a fifth

After fully adjusting their models to account for other variables that could affect the results, the team found that those with the highest omega-3 index were 21 percent less likely to test positive for COVID than those with the lowest levels. The risk for a positive test was actually eight percent lower for every standard deviation increase in plasma DHA percentage. Additionally, patients with the highest omega-3 index were 26 percent less likely to need hospitalization than those with the lowest.

https://b5c290d7f3674d0d7b0e2b3e92ef07e7.safeframe.googlesyndication.com/safeframe/1-0-40/html/container.html

Among patients who died of COVID-19, trends weren’t as significant. Risk of severe infection was lower in those with the second highest omega-3 index. In the highest bracket, the risk reduction was actually minimal and statistically insignificant.

Sardines packaged on ice
(Photo by Harris Vo on Unsplash)

https://b5c290d7f3674d0d7b0e2b3e92ef07e7.safeframe.googlesyndication.com/safeframe/1-0-40/html/container.html

“This study confirms previous findings that low omega-3 status is associated with increased risk for hospitalization with COVID-19. We extended these findings by also showing reduced risk for testing positive with the infection and by providing evidence that the risk for death may also be reduced,” says Dr. William S. Harris, President of Fatty Acid Research Institute, in a media release. “Furthermore, we identified the Omega-3 Index levels associated with the least and greatest protection from COVID-19. Altogether these results support the practice of increasing consumption of oily fish like salmon or omega-3 fish oil supplements as a potential risk reduction strategy when it comes to COVID-19.”

Certain countries enjoy even great protection

The team adds that there seems to be a global pattern as well, as found in previous work. South Korea and Japan have both reported very low severity of COVID-19. Although these countries are very diligent about masking, social distancing, and other spread mitigation practices, there is a fascinating connection between Omega-3 Index values of healthy South Korean and Japanese individuals and COVID-19 outcomes. In these nations, indexes are about 8-12 percent and 7-11 percent respectively, which is significantly higher than the 4-5 percent in Western countries like the United States.

“A worldwide pattern linking higher omega-3 fatty acid intakes with lower rates of death with COVID-19 was documented by Vivar-Sierra et al. Although only suggestive, this observation adds further support for a potential role of omega-3s EPA and DHA in the prevention of fatal COVID-19 disease,” the study authors report.

https://b5c290d7f3674d0d7b0e2b3e92ef07e7.safeframe.googlesyndication.com/safeframe/1-0-40/html/container.html

These findings back the notion that including omega-3 fatty acids in your diet is essential for a well-rounded, healthy diet. However, they also show that by possibly reducing severe infections from COVID-19, there may be even more of an incentive to getting enough in your daily diet.

The findings are published in the American Journal of Clinical Nutrition.

Tags: coronavirus, COVID-19 symptoms, fish oil, oily fish, omega-3

Random ArticleNext Article

Leave a Comment

About the Author

Shyla Cadogan

Shyla Cadogan is a recent graduate from the University of Maryland, College Park with a Bachelor’s of Science in Nutrition and Food Science. She is on her way to becoming a Registered Dietitian, with next steps being completion of a dietetic internship at the University of Maryland Medical Center where she currently is gaining experience with various populations and areas of medical nutrition such as Pediatrics, Oncology, GI surgery, and liver and renal transplant. Shyla also has extensive research experience in food composition analysis and food resource management.

Mediterranean Diet and Dementia?

“There are around 50 million dementia cases globally, with around 10 million new cases discovered by doctors every year. Alzheimer’s disease makes up 50 to 70 percent of those cases. Its development and progression have links with both genetic and environmental factors, including diet and lifestyle.”

The Mediterranean Diet scores have high marks again when assessed for dietary effects on dementia.

https://studyfinds.org/mediterranean-diet-dementia-alzheimers-disease/

Why do some people get Covid more severely than others?

COVID-19 strikes with alarming inconsistency. Most recover quickly while others die. The disease devastates some communities and spares others. Understanding why and how COVID-19 preys on some and not others is essential to limiting its spread and mitigating its impact.

Prevention, averting, detecting, and restricting disease, is always better than even the most effective treatment. In the first place, We need answers to verify the findings of any new promising study.

Ever wonder why some places on the globe suffer from the virus so differently than others? Can the Blue Zones populations give us some answers?

https://www.bluezones.com/2020/05/why-covid-19-hits-some-people-and-places-differently/#

Can Ultraprocessed Food Contribute to Dementia?

 Is Eating Fast Food a Dementia Risk? 

The health risks of eating ultraprocessed foods —including sausages and burgers as well as pizza and ice cream — are well documented. They have been shown to raise the risk of obesity, diabetes, and cancer among other ailments. (CNN.com). 

In a new study, researchers followed more than 10,000 Brazilians with an average age of 51 for more than 10 years. They found that people who consumed more than 20% of their daily calories from ultra processed foods had a 28% faster cognitive decline compared with those whose intake was less than 20%.  Unfortunately, that 20% is not a high threshold: just 400 calories out of the 2000 calorie diet. And most Americans are well over that, getting on average a whopping 58% of their calories from ultraprocessed foods.

 “The sample size is substantial and the followup extensive,” says Dr. David Katz, a nutrition specialist who was not involved in the study. While short of proof, this is robust enough that we should conclude ultraprocessed foods are probably bad for our brains,” 

Source: The Week. December 23, 2022, Volume 22, Issue 110.

Why Is Epigenetics Important?

“The epigenome is a network of compounds surrounding our genes, which interacts with our environment, altering gene expression to external influences.”

“Although our DNA code does not change, the epigenome is flexible and reacts to our environment. Beyond helping cells know what to do, the epigenome also responds to things like diet, stress, toxins, behavior, and lifestyle. Our experiences help shape how genes are expressed. It is often referred to as an “on and off switch” that turns on or off certain genes. It is what makes even identical twins different over time.”

CLICK HERE.

Does Aging Cause Vitamin Deficiencies?

Written by Kathleen Doheny

Reviewed by Louise Chang, MD on November 30, 2012

Nov. 30, 2012 — At least half of adults age 65 and above take daily vitamins and other supplements, but only a fraction actually need them, says an Emory University expert.

The majority of older adults, he says, can improve their diet to get needed nutrients.

“A lot of money is wasted in providing unnecessary supplements to millions of people who don’t need them,” says Donald B. McCormick, PhD, an Emory professor emeritus of biochemistry and the graduate program in nutrition and health sciences at Emory.

He challenges what he says is a widely held belief that the older people get, the more vitamins and mineral supplements they need.

The scientific backup for that doesn’t exist, he says. “We know too little to suggest there is a greater need in the elderly for most of these vitamins and minerals.”

“A supplement does not cure the aging process,” he says. And in some cases, supplements may do harm, he says. Expense is another factor.

His report, which reviews numerous studies of vitamins and mineral supplements, is published in Advances in Nutrition.

Duffy MacKay, ND, vice president of scientific and regulatory affairs for the Council for Responsible Nutrition, an industry group representing dietary supplement makers, agrees that starting with a good diet is the best way to get needed nutrients.

But he says that is not always reality, especially for older adults who may have obstacles such as a reduced appetite.

Older-Adult Nutrient Needs

McCormick reviewed studies on dietary supplements in older adults published in the last 12 years.

He says that ”it is apparent that changes in requirements for the elderly do not suggest massive supplement use covering most micronutrients.” He says minor diet changes can fill needs for nutrients, ”with supplements included only where there is evidence of serious limitation of intake.”

He disagrees with a study suggesting that older adults should take two multivitamins a day. He found no evidence that older adults need more thiamin, riboflavin, or niacin than younger people. Some older adults may need more vitamin B6, B12, and folate, research suggests.

But vitamin C needs do not seem to change with age, he says, if an older adult does not smoke cigarettes.

McCormick also found no evidence that absorption or the body’s use of vitamin E changes as people get older. He says there is a decrease in the way the skin makes vitamin D. So for some older adults, supplemental vitamin D may be needed. In some research, taking 800 to 1,000 IUs of vitamin D a day helped women who were past menopause.

Copper requirements don’t seem to change with age, either, McCormick says.

Older adults often take in less chromium, but he says there is not evidence that there are any health consequences.

In his report, McCormick says supplements for cancer patients are not recommended. (His report was finalized before recent research linked the use of a daily multivitamin to decreased cancer risk modestly in male doctors age 50 and older.) “The jury is still out.” (SJF).

For older adults, McCormick has this advice: “If you are still eating fairly well, you are getting more micronutrients than you probably really need to function as well as you can.”

Boosting nutrients above what can be gotten from a well-balanced diet won’t necessarily lead to better health, he says.

At very high levels, some vitamins and minerals can be toxic, he says.

Perspectives: Vitamins, Supplements for Older Adults

”The adequate intake of vitamins in the elderly is a concern,” MacKay of the Council for Responsible Nutrition says.

In particular, he says, older adults may lack calcium, vitamin D, vitamin B12, potassium, and fiber.

Changing the diet can be difficult for older people, he says. Living on fixed incomes may make fresh produce too costly.

Some older adults don’t know how to cook. For others, ill-fitting dentures or a reduced appetite may make eating difficult.

“Where dietary changes are difficult, a dietary supplement can be a responsible, reasonable solution,” he says.

The Academy of Nutrition and Dietetics says older adults should pay special attention to their intake of calcium, vitamin D, vitamin B-12, potassium, and fiber.

Fortified milk and yogurt can boost calcium and vitamin D. Lean meat, fortified cereal, and some fish and seafood have vitamin B12. Fruits and vegetables have potassium and fiber.

“It’s always best to obtain your nutrients from food,” says Andrea Giancoli, RD, MPH, a spokeswoman for The Academy of Nutrition and Dietetics. She reviewed the report for WebMD.

When she counsels older adults, Giancoli first figures out what nutrients are lacking in the diet. Often, it’s vitamin D, calcium, and vitamin B12.

“I try to fix it with food,” she says. For instance, she suggests someone with calcium deficits increase their dairy products.

“I don’t think we should be recommending supplements blindly without assessing their food intake,” she says.

Bottom Line:

“Supplements are a multi-billion-dollar industry, and a lot of that is marketing. But the argument that supplments are useless and everybody should stop wasting their money is also overblown: There are gaps left by the typical American diet, and those gaps can be plugged with the judicious use of supplements. But if your diet is good, the supplements you take should be minimal.”

Source: Mark Bittman and David L. Katz, MD. How to Eat: All your food and diet questions answered. 2020

From SJF: Supplements should not be taken in what is found in many popular products and dosages called megadoses, Some supplements can be toxic, i.e.amounts in huge percentages over the RDA. These values can be found in any nutrition textbook as Tolerable Upper Intake Levels (UL) for Vitamins and Tolerable Uppper Intake Levels (UL) for Minerals and reading supplement labels can provide megadose amounts if present in the product. Consult your doctor who may have prescribed these doses for a medical problem.

SOURCES:

Donald B. McCormick, PhD, professor emeritus of biochemistry and graduate program in nutrition and health sciences, Emory University, Atlanta.

Duffy MacKay, ND, vice president of scientific and regulatory affairs, The Council for Responsible Nutrition.

Andrea Giancoli, MPH, RD, spokesperson, The Academy of Nutrition and Dietetics.

McCormick D. Advances in Nutrition, November 2012.

Diet and Lifestyle

Healthy Eating Linked to Lower Risk of Total Mortality

— Lower risks of death due to cardiovascular disease, cancer, respiratory disease noted

by Kristen Monaco, Staff Writer, MedPage Today January 9, 2023

Share on Facebook. Opens in a new tab or window

Share on Twitter. Opens in a new tab or window

Share on LinkedIn. Opens in a new tab or window

email article

A photo of a couple serving dinner in their kitchen.

Adhering to healthy eating patterns was associated with lower risk of total and cause-specific mortality, a prospective cohort study with up to 36 years of follow-up showed.

Among 75,230 women from the Nurses’ Health Study and 44,085 men from the Health Professionals Follow-up Study, those who scored in the highest quintile for healthy eating patterns recommended by the Dietary Guidelines for Americans (DGAs) had a 14% to 20% lower risk of total mortality versus those in the lowest quintile, reported Frank Hu, MD, PhD, of the Harvard T.H. Chan School of Public Health in Boston, and colleagues in JAMA Internal Medicineopens in a new tab or window.

The pooled multivariable-adjusted hazard ratios of total mortality with four healthy eating patterns were (P<0.001 for trend for all):

  • Healthy Eating Index 2015 (HEI-2015): HR 0.81 (95% CI 0.79-0.84)
  • Alternate Mediterranean Diet (AMED): HR 0.82 (95% CI 0.79-0.84)
  • Healthful Plant-Based Diet Index (HPDI): HR 0.86 (95% CI 0.83-0.89)
  • Alternate Healthy Eating Index (AHEI): HR 0.80 (95% CI 0.77-0.82)

This lower risk was consistent across all racial and ethnic groups.

“This is one of the largest and longest-running studies that examine the associations of dietary scores for four healthy eating patterns recommended by the DGAs with the risk of total and cause-specific mortality in large cohort studies,” Hu told MedPage Today.

“Every 5 years, the U.S. Department of Agriculture (USDA) and U.S. Department of Health and Human Services (HHS) release an updated version of the Dietary Guidelines for Americans,” he explained. “It is important to evaluate adherence to DGA-recommended eating patterns and health outcomes, especially mortality, so that timely updating of DGAs can be made.”

Hu noted that these findings will be valuable for the 2025-2030 Dietary Guidelines Advisory Committee, which is being created by the USDA and HHS to evaluate the current evidence on different eating patterns and health outcomes.

Beyond total mortality, healthier diets were also significantly linked to lower risk of cause-specific mortality.

Across the four different dietary patterns, people in the highest quintile saw a 6% to 13% lower risk of death from cardiovascular disease versus those in the lowest quintile. Likewise, those in the highest quintile saw a 6% to 15% lower risk of death due to heart disease, a 7% to 18% lower risk of cancer-related death, and a 35% to 46% lower risk of respiratory disease-related death.

In addition, those with the highest scores on the AMED and AHEI also saw a modestly lower risk of death due to neurodegenerative disease (HR 0.94, 95% CI 0.90-0.99 and HR 0.93, 95% CI 0.87-0.99, respectively).

“Although previous studies have found an inverse association between healthy eating patterns and mortality, our study provides evidence that healthy eating patterns reduce the risk of cause-specific mortality including cardiovascular disease, cancer, respiratory, and neurodegenerative mortality,” said Hu. “The findings on respiratory and neurodegenerative mortality are novel.”

However, eating a healthy diet according to any of the four patterns did not appear to be protective against stroke-related deaths.

Hu said clinicians can recommend a “variety of healthy dietary patterns” to patients in order to reduce their risk for chronic diseases and premature death.

“These patterns such as the Mediterranean diet, DASH diet, vegetarian diet, or other versions of healthy diets can be adapted to meet individual health needs, food preferences, and cultural traditions,” he noted. “These healthy dietary patterns typically include high amounts of plant foods such as fruits, vegetables, whole grains, nuts, and legumes, and lower amounts of refined grains, added sugars, sodium, and red and processed meats.”

“It is also important to balance caloric intake with physical activity to maintain a healthy weight,” he added.

Among the women included in the analysis, mean baseline age was 50.2 and 98% were white; for men, mean age was 53.3 and 91% were white. In total, 31,263 women and 22,900 men died during follow-up. The leading cause of death was cancer, followed by cardiovascular disease, heart disease, neurodegenerative disease, respiratory disease, and stroke.

Dietary data were taken from semiquantitative food frequency questionnaires including more than 130 items, which were completed every 2 to 4 years.

  • author['full_name'] Kristen Monaco is a staff writer, focusing on endocrinology, psychiatry, and nephrology news. Based out of the New York City office, she’s worked at the company since 2015.

Disclosures

The study was supported by a grant from the National Heart, Lung, and Blood Institute.

Hu reported no disclosures. Other co-authors reported relationships with Kubara Honke, Grants-in-Aid for Scientific Research, the G-7 Scholarship Foundation, the Japan Diabetes Society, the LOTTE Foundation, Layer IV, the U.S. Department of Agriculture, the U.S. Highbush Blueberry Council, the National Institutes of Health, Mars Edge, and the National Heart, Lung, and Blood Institute.

Primary Source

JAMA Internal Medicine

Source Reference: opens in a new tab or windowShan Z, et al “Healthy eating patterns and risk of total and cause-specific mortality” JAMA Intern Med 2023; DOI: 10.1001/jamainternmed.2022.6117.

Vitamin D and Mortality – In the News

Improving vitamin D levels in Older Age is Linked to Lower risk of all-cause Mortality

Sources: BMC Geriatr 22, 245 (2022)
LIfe Extension, Feb. 2023

Judith E. Brown. Nutrition Now, 7th Edition

The participants in this study included 1,362 individuals in the Chinese Longitudinal and Health Longitudinal Survey, aged 60 to 113 whose serum vitamin D levels were measured in 2012 and 2014. Mortality data were collected in 2018.

Deficient vitamin D levels were detected in 67.5% of the participants in 2012 and 68.4% in 2014.

During follow-up, 420 deaths occurred. Individuals who were deficient in vitamin D in 2012 and 2014 had more than twice the mortality risk than those who maintained higher levels.

Among participants who maintained sufficient vitamin D were deficient in 2012 and not deficient in 2014, the risk of dying was 30% and 53% lower, respectively, compared to participants who were deficient at both points in time.

This highlights the need to address vitamin D deficiency in older individuals to support longevity and healthy aging.

Editor’s Note: The greatest benefit associated with improved vitamin D status was found among women and those people who were 80 years of age or older.

What are the primary functions of vitamin D? This fat-soluble vitamin is needed for absorption of calcium and phosphorus needed for bone formation and muscle activity. It inhibits inflammation and is involved in insulin secretion and blood glucose level maintenance. It can be toxic with the long term use of 10,000 IU daily. The RDA is 600 IU for adult women and men; the Upper Tolerable Intake (UL) is 4,000 IU.s or 100 ug.

This highlights the need to address vitamin D deficiency in older individuals. Based on the evidence for bone benefits, however, a nutrition panel recently increased the RDA for vitamin D to 600 IU for people up to age 70 and to 800 IU for those over 70. That’s a fairly sizable boost over the previous recommendations of 200 IU per day through age 50, 400 IU for ages 51 to 70, and 600 IU for ages over 70. They also raised the safe upper limit of daily intake for most age groups from 2,000 to 4,000 IU. to support longevity and healthy aging. 1 microgram vitamin D = 40 IU as both terms are used on supplement labels. It is primarily found only in vitamin D-fortified milk, cereals, and other foods such as fish.

The best way to measure effects of supplemental intake or vitamin D status is by a blood test. Vitamin D3 is the most active form and is made from a form of cholesterol in the skin cells upon exposure to ultraviolet rays from the sun. See your doctor for guidance.

Diet, Exercise, and Diabetes

Diet and Exercise

There have been several studies in the past that promote lifestyle factors and compare them to drug treatments like metformin. For diabetes type 2 including pre-diabetes – here is another one – too bad more physicians are not “prescribing” this intervention instead of putting their patients on one drug after another to control diabetes type 2.

“Researchers randomly assigned 100 sedentary adults aged 65 to 85 with type 2 diabetes and overweight or obesity to either an intensive lifestyle intervention or a control group that only had monthly sessions about a healthy diet.  

A dietitian helped the intensive group consume a diet with sufficient protein, vegetables, fruits, and whole grains and 500 to 750 fewer calories a day. The group also did 90 minutes of aerobic and resistance training three times a week.

After a year, the intensive group had lost 18 pounds and the control group lost virtually zero. The intensive group also gained more strength and fitness and had lower hemoglobin A1c (a long-term measure of blood glucose) and better insulin sensitivity.

The authors recommended that if you have diabetes type 2, Medicare covers behavioral therapy for obesity, and some Medicare Advantage plans offer gym memberships.”

Diabetes Care 2022. doi: 10.2337/dc22-0338.

In the News: Vitamin D

Low levels of vitamin D linked to poor cognitive function

Source: Medical News Today, Sunday, December 11, 2022
<newsletter@newsletter.medicalnewstoday.com>
“There is growing evidence for how your body relies on vitamin D to ward off inflammation, cancer, and heart disease. Having enough of it in your blood is linked to a lower risk of dying prematurely. But what about vitamin D and the brain? What is its role in cognition, or dementia, if any? As one researcher told Medical News Today this week, “we did not know if vitamin D was even present in the human brain.”

The researcher, Kyla Shea, PhD, is lead author of a study offering the first evidence that vitamin D is not only present in the brain, a healthy level of it is associated with better cognitive function and a lower risk of dementia in older adults.

The evidence comes from the postmortem study of the brains of 290 individuals who had agreed to donate their organs after death. Researchers found that higher concentrations of vitamin D across the brain were associated with up to a 33% lower chance of developing dementia.

It is early days, so precisely how vitamin D supports healthy cognitive function is not yet understood. Dr. Shea sees signs that it is involved in cell-signaling pathways that may be part of neurodegeneration, but more research is needed to build on this groundbreaking study.” Stay tuned???